Bobcat339 hydrochloride( —— )

Catalog No. M35499 CAS No. 2436747-44-1

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Product Name

Bobcat339 hydrochloride
Note

Research use only, not for human use.
Brief Description

Bobcat339 hydrochloride can be used in the field of epigenetics and as a starting point for new therapeutics targeting DNA methylation and gene transcription.
Description

Bobcat339 hydrochloride is a potent and selective cytosine-based inhibitor of TET enzyme, with the IC50s of 33 μM and 73 μM for TET1 and TET2, respectively. Bobcat339 hydrochloride is useful to the field of epigenetics and serves as a starting point for new therapeutics that target DNA methylation and gene transcription.
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

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Indication

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CAS Number

2436747-44-1
Formula Weight

334.2
Molecular Formula

C16H13Cl2N3O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 125 mg/mL (374.03 mM; Ultrasonic )H2O : < 0.1 mg/mL (insoluble)
SMILES

Cl.Nc1nc(=O)n(cc1Cl)-c1cccc(c1)-c1ccccc1
Chemical Name

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1. Chua GNL, et al. Cytosine-Based TET Enzyme Inhibitors. ACS Med Chem Lett. 2019 Jan 31;10(2):180-185.?

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